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4.2 ApoM/S1P signaling pathway Gut vascular barrier (GVB), a novel anatomical structure in the mouse and human gut described by Spadoni et al., in 2015, is composed of vascular endothelial cells, pericellular fibroblasts, enteric glial cells, as well as junction complexes including tight junctions (TJs) and adhesion junctions (AJs) (Ge et al., 2020)
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